IS: invited speakers
OP: selected oral presentation
YIB/YIC: Young investigators session basic or clinical
Günter Wagner: The inflammatory origin of mammalian implantation
Immune dysregulation in infertility and implantation failure
Sarah Robertson: Interferon-G in seminal fluid – an “anti-tolerance” signal in women?
Yuye Li: Study on quantity and function of CD8+T cells in patients with repeated implantation failure.
Nathalie Ledee: The uterine immune-profiling in recurrent pregnancy loss and recurrent implantation failures.
Longfei Li: Immune profiles in the endometrium during implantation window and in the decidua of early pregnancy
Su Liu: Impaired peripheral blood HLA-G+ T cells are associated with recurrent miscarriage and recurrent implantation failure.
Timea J. Csabai: The effect of light exposure on the cleavage rate and implantation capacity of preimplantation murine embryos
The role of the maternal placental and gut microbiota in complications of pregnancy and during childhood/ Immunology of male factor infertility
Indira Mysorekar: Spatial and temporal organization of placental microbial communities: Implications for maternal-fetal crosstalk
Li-Ling Wang: Expression pattern and localization of PD-1 and PD-L1 in the testicular tissues of mice.
Gry Persson: Cytokine stimulation of the choriocarcinoma cell line JEG-3 leads to altered HLA class Ib expression profile.
Thor Haahr: Vaginal, cervical and uterine pH in women with normal and abnormal vaginal microbiota.
Anna Havrylyuk: The differences between immune disorders in infertile men with reproductive system abnormalities and systemic autoimmune diseases.
Indira Mysorekar: Mechanisms underlying Zika virus transplacental infection route during pregnancy.
Young Investigators Session- Basic
Zhi-Hui Li: Aberrant Tim-3/Gal-9 pathway involved in the pathogenesis of pre-eclampsia in rat model by regulating the polarization of decidual macrophages
Kirsten Thiele: CD4+ regulatory T cell frequencies are functionally involved in the improved outcome of secondary pregnancies in mice.
Pia Egerup: Pregnancy in kidney-transplanted women: A national cohort study on pregnancy outcomes in kidney-transplanted women and the long-term risk for their offspring.
Midori Yoshikawa: Reactive oxygen species-mediated activation of apoptosis signal-regulating kinase1 (ASK1) plays a pivotal role in inflammation-induced preterm birth.
15.00-16.00 Young Investigators Session- Clinical
Amruta D.S. Pathare: Aberrant immunological response in endometrial receptivity among IVF implantation failure patients revealed by whole genome gene expression and methylation profiling: A pilot study.
Nobuko Mimura: Association of eicosapentaenoic acid (EPA) to arachidonic acid (AA) ratio with second trimester miscarriage.
Louise M. Kofod: Endometrial immune markers are potential predictors of normal fertility and pregnancy success.
Valentina Bruno: Low molecular weight heparin effects on the immune response during pregnancy in women with unexplained recurrent pregnancy loss.
Interactions between the endocrine, nervous and immune system in pregnancy.
Julia Szekeres-Bartho: Bidirectional communication between the embryo and the maternal immunoendocrine system
Maria Emilia Solano: Stress-induced foetal glucocorticoid excess: sex specific regulation at the placenta.
Jan Ernerudh: Cytokines and chemokines in immune regulation during pregnancy
Anne Schumacher: IL-10 secretion and plasma cell alloantigen 1 define two distinct B1a B cell subsets with opposite functions during pregnancy.
Marilen Benner: Uterine immune dynamics assessed from pre-pregnancy endometrium to delivery.
Rodolfo Favaro: Development of a 3D in vitro model for the assessment of endometrium-trophoblast interactions.
Immunogenetics and early and late pregnancy complications
Thomas VF: Hviid: HLA in reproduction – from implantation to pregnancy disorders.
Kim van Bentem: The development of pre-eclampsia in oocyte donation pregnancies is related to the number of HLA class II mismatches.
Frans Claas: HLA-C, an important player in the immune regulation of pregnancy.
Michael Eikmans: Women with a history of recurrent miscarriage have a genetic predisposition to the HLA-G 3´UTR 14-bp insertion allele but increased HLA-G expression in their term placenta.
Bo Jacobsson: Genetics of gestational duration and preterm delivery – the first replicated findings, how did we get here and the road forward.
Current status of NK, T and decidual stromal cells in reproduction
Bettina Toth: NK subsets in recurrent miscarriage and post-renal transplantation patients
Robert Lindau: Decidual stromal cells induce homeostatic M2 macrophages and regulatory T cells.
Günter Wagner: The uterine decidual stromal cell: a stabilized stress response
Dorien Feyaerts: Endometrial natural killer cells reveal a tissue-specific receptor repertoire.
Johanna Raffetseder: Frequency and phenotype of mucosal-associated invariant T (MAIT) cells during pregnancy.
Immunotherapy in recurrent implantation failure and pregnancy loss/clinical aspects of pregnancy complications
Ole B. Christiansen: Status of intravenous immunoglobulin in the treatment of recurrent pregnancy loss and implantation failure.
Emma R. Roepke: Is the incidence of recurrent pregnancy loss increasing? A retrospective register-based study in Sweden
James R. Scott: Reproductive immunology seen from the perspective of a clinician.
Manon Bos: Changes in the reactive species interactome in oocyte donation pregnancies and pre-eclampsia.
Round table debate with James R. Scott, Sarah Robertson, Bettina Toth, Ole B Christiansen, Juana Gil Herrera: Pro et contra the use of immunomodulation in recurrent pregnancy loss and implantation failure
Brice Gaudilliere: Single cell profiling of the maternal immune clock of pregnancy
19.30 Gala dinner
The role of extracellular vesicles and exosomes in reproduction
Udo Markert: Trophoblast-immune cell communication via micro-RNA transported in extracellular vesicles
Rachel Zabel: Exosomes isolated from trophoblast cells cultured in high or low glucose change the metabolism of endometrial epithelial cells.
Malene Moeller Joergensen: Treatment with intravenous immunoglobulin increases the level of small extracellular vesicles in plasma of pregnant women with recurrent spontaneous abortion
Marei Sammar: Syncytiotrophoblast derived micro- and nano-vesicles from term human placentae carry placental protein-13 (PP13) and levels are decreased in preeclampsia
Cellular and molecular mechanisms in fetal tolerance
Guillermina Girardi: Complement activation in preeclampsia and preterm birth
Mie Crussel: Gestational diabetes is associated with an aberrant gut microbiota during pregnancy and postpartum
Maria Jenmalm: The mother-offspring dyad, microbial transmission, immune interactions and allergy development
Maria Svenvik: Threatened preterm birth and time of delivery; differences in biomarkers and maternal characteristics.
OP 12.30 -12.45
Chiara Agostinis: The complement component C3 is expressed by the endometrial ectopic tissue and is involved in the endometriotic lesion formation.
Naoya Akiba: Progranulin as a key mediator in cervical ripening.
Biomarkers in late pregnancy complications; present knowledge and future directions
Petra Arck: The vertical transfer of maternal immune cells during pregnancy: from identification to function
Niels Toerring: Autoantibodies to the Endothelin-1 Receptor type A and the Angiotensin II Receptor type 1 in Patients with pregnancy induced hypertension and Preeclampsia.
Bo Jacobsson: Inflammatory biomarkers in vaginal fluid and umbilical cord blood in intraamniotic inflammation and preterm birth
Roberta Bulla: Analysis of anti-C1q antibodies in normal and pathological pregnancies.
Which immune investigations and treatments are recommended in clinical guidelines?
Ole B. Christiansen and Katharina Feil/Bettina Toth: The new ESHRE/DGGG/OEGGG and SGGG guidelines on recurrent pregnancy loss: are they fair to reproductive immunology?